nanoparticles for therapeutic use (rus. наночастицы, терапевтические) — biocompatible nanoparticles with defined properties (incl. size, morphology, surface properties) used for diagnostics and treatment of diseases.

Description

Composite nanoparticles comprised of a perfluoridecarbon [1], silicon or golden core [2,3] coated with a biocompatible lipid or polymer shell are one of the most common types of particles for therapeutic use. Similar to superparamagnetic nanoparticles based on metals and their oxides, such as iron oxide, these nanoparticles (e.g., containing paramagnetic gadolinium) can be used as a contrast agent in magnetic resonance imaging, for vectored drug delivery, photodynamic therapy, etc.

Illustrations

Microphotograph (TEM) of gold nanocells with polymer on the surface used for delivery of pharma
Microphotograph (TEM) of gold nanocells with polymer on the surface used for delivery of pharmaceuticals. Authors: Mustafa S. Yavuz, Yiyun Cheng, Jingyi Chen, Washington University, USA [3].

Authors

  • Goodilin Evgeny A.
  • Shirinsky Vladimir P.

Sources

  1. Winter P.M. et al. Emerging nanomedicine opportunities with perfluorocarbon nanoparticles // Expert Rev. Med. Devices. 2007. V. 4. P. 137–145.
  2. Lim Y. T. et al. Paramagnetic gold nanostructures for dual modal bioimaging and phototherapy of cancer cells // Chem. Commun. (Camb.). 2008. V. 40. P. 4930–4932.
  3. Mustafa S. et al. Gold nanocages covered by smart polymers for controlled release with near-infrared light // Nature Materials. 2009. V. 8. P. 935–939.

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